SwissPalm: Protein Palmitoylation database
نویسندگان
چکیده
منابع مشابه
SwissPalm: Protein Palmitoylation database
Protein S-palmitoylation is a reversible post-translational modification that regulates many key biological processes, although the full extent and functions of protein S-palmitoylation remain largely unexplored. Recent developments of new chemical methods have allowed the establishment of palmitoyl-proteomes of a variety of cell lines and tissues from different species. As the amount of infor...
متن کاملPalmitoylation-dependent protein sorting
S-palmitoylation is a posttranslational modification that regulates membrane-protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.
متن کاملProtein palmitoylation in protozoan parasites.
Palmitoylation plays an important role in the regulation of the localization and function of the modified protein. Although many aspects of protein palmitoylation have been identified in mammalian and yeast cells, little information is available of this modification in protozoan parasites. Protein palmitoylation has been described for a few set of proteins in E.tenella, P. falciparum, T. gondii...
متن کاملProtein palmitoylation in membrane trafficking
Introduction Protein palmitoylation was first described more than 20 years ago for the myelin proteolipid protein, but the functional significance of this post-translational modification remains obscure. Progress has been hampered by the lack of specific inhibitors for acylation and because of the difficulty of developing an assay to isolate the palmitoylating enzyme(s). Palmitoylation generall...
متن کاملSpecificity of Transmembrane Protein Palmitoylation in Yeast
Many proteins are modified after their synthesis, by the addition of a lipid molecule to one or more cysteine residues, through a thioester bond. This modification is called S-acylation, and more commonly palmitoylation. This reaction is carried out by a family of enzymes, called palmitoyltransferases (PATs), characterized by the presence of a conserved 50- aminoacids domain called "Asp-His-His...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2015
ISSN: 2046-1402
DOI: 10.12688/f1000research.6464.1